Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | STS | P08842 | 5/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ELANE | P08246 | 2/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6938536 | 1.00 | L3MBTL1 (0.53) | L3MBTL1ATMTDP1STSSRD5A2 | |
| SCHEMBL28459005 | 0.87 | AKR1C3 (0.56) | KMT2AAKR1C3KDM4E | |
| SCHEMBL28649673 | 0.85 | ELANE (0.58) | L3MBTL1STSSRD5A2ALDH1A1ELANE | |
| SCHEMBL757838 | 0.81 | SMN1; SMN2 (0.51) | L3MBTL1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL757114 | 0.81 | SMN1; SMN2 (0.51) | L3MBTL1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL757113 | 0.81 | SMN1; SMN2 (0.51) | L3MBTL1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL5245757 | 0.80 | L3MBTL1 (0.57) | L3MBTL1ATMTDP1STSSRD5A2 | |
| SCHEMBL28064519 | 0.79 | LMNA (0.67) | L3MBTL1ATMMEN1KMT2AALDH1A1 | |
| SCHEMBL30414806 | 0.78 | MEN1 (0.69) | L3MBTL1ATMTDP1STSMEN1 | |
| SCHEMBL755443 | 0.78 | MEN1 (0.69) | L3MBTL1ATMTDP1STSMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888278-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-0888278-A4 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0888278-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997028115-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |