⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2953104 | 0.98 | ALDH1A1 (0.50) | — | |
| SCHEMBL14008412 | 0.82 | ALDH1A1 (0.55) | — | |
| SCHEMBL6935658 | 0.78 | ALDH1A1 (0.47) | — | |
| Bromide SCHEMBL2955255 | 0.76 | ALDH1A1 (0.50) | — | |
| SCHEMBL10595348 | 0.68 | SMN1; SMN2 (0.40) | — | |
| SCHEMBL14008410 | 0.67 | ALDH1A1 (0.69) | — | |
| SCHEMBL7074123 | 0.67 | ALDH1A1 (0.69) | — | |
| SCHEMBL31623847 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL420325 | 0.65 | KMT2A (0.54) | — | |
| SCHEMBL16624835 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808163-B1 | USE OF THIAZOLIUM COMPOUNDS FOR PREVENTING AND REVERSING THE FORMATION OF ADVANCED GLYCOSYLATION ENDPRODUCTS | ALTEON INC (US) | 2003-07-23 | — | — | EP | claimed |
| US-6440749-B1 | ADMINISTERING A THIAZOLE COMPOUND | ALTEON. INC. | 2002-08-27 | — | — | US | claimed |
| US-6007865-A | FOR INHIBITING AND REVERSING NONENZYMATIC CROSS-LINKING (PROTEIN AGING), TREATING KIDNEY DAMAGE AND TREATING COMPLICATIONS OF DIABETES, PREVENTING FOOD SPOILAGE | ALTEON INC. | 1999-12-28 | — | — | US | claimed |
| US-9622469-B2 | Crosslink breakers for preservation of biological substances | SPIEGEL DAVID (US) | 2017-04-18 | — | — | US | disclosed |
| US-20150099260-A1 | Crosslink Breakers for Preservation of Biological Substances | SPIEGEL DAVID (US) | 2015-04-09 | — | — | US | disclosed |
| US-20080293931-A1 | Methods and compositions for the removal of nucleic acid amplification inhibitors | LOS ALAMOS NATIONAL SECURITY, LLC | 2008-11-27 | — | — | US | disclosed |
| US-20070065841-A1 | Methods and compositions for the removal of nucleic acid amplification inhibitors | ENERGY, U.S. DEPARTMENT OF | 2007-03-22 | — | — | US | disclosed |