SCHEMBL693976

SCHEMBL693976

O=[N+]([O-])c1ccc(OC(F)(F)F)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSPB1 P04792 2/20 0.55
MAPT P10636 3/20 0.52
KMT2A Q03164 3/20 0.52
TP53 P04637 2/20 0.52
MEN1 O00255 2/20 0.52
CASP3 P42574 1/20 0.52
HTT P42858 1/20 0.52
NPSR1 Q6W5P4 1/20 0.52
SENP7 Q9BQF6 1/20 0.52
PGR P06401 1/20 0.49
CA1 P00915 3/20 0.48
CA2 P00918 3/20 0.48
CA9 Q16790 2/20 0.48
CES2 O00748 1/20 0.48
CES1 P23141 1/20 0.48
PSD A5PKW4 1/20 0.46
CA5A P35218 1/20 0.46
ALDH1A1 P00352 4/20 0.45
SMN1; SMN2 Q16637 3/20 0.45
LMNA P02545 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1241412 0.94 HSPB1 (0.65) HSPB1MAPTKMT2ATP53MEN1
SCHEMBL1242136 0.94 PGR (0.52) HSPB1MAPTKMT2ATP53MEN1
SCHEMBL10983646 0.89 PGR (0.55) HSPB1MAPTKMT2ATP53MEN1
SCHEMBL13581180 0.89 MAPT (0.54) HSPB1MAPTKMT2ATP53MEN1
SCHEMBL9325813 0.86 HSPB1 (0.53) HSPB1MAPTKMT2ATP53MEN1
SCHEMBL12952828 0.85 CA12 (0.61) MAPTKMT2ATP53MEN1NPSR1
SCHEMBL11942626 0.85 POLB (0.62) MAPTPGRALDH1A1SMN1; SMN2LMNA
SCHEMBL10773169 0.84 HSPB1 (0.52) HSPB1MAPTKMT2ATP53MEN1
SCHEMBL10912860 0.84 HSPB1 (0.52) HSPB1MAPTKMT2ATP53MEN1
SCHEMBL15388537 0.84 HSPB1 (0.52) HSPB1TP53HTTCA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 106 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120064487-A Detection method of 4-trifluoromethoxy aniline related substances 石家庄四药有限公司 2025-05-30 CN claimed
CN-120040289-A Method for synthesizing p-nitro trifluoro-methoxybenzene by micro-channel 恒劲生物技术(大连)有限公司 2025-05-27 CN claimed
CN-115322107-B Method for preparing p-trifluoromethoxy aniline through continuous hydrogenation 金凯(辽宁)生命科技股份有限公司 2025-04-18 CN claimed
CN-118894609-B Phosphorus-free composite scale inhibitor and preparation method thereof 宜兴汉光高新石化有限公司 2025-02-11 CN claimed
CN-118894609-A High-temperature-resistant phosphorus-free composite scale inhibitor and preparation method thereof 宜兴汉光高新石化有限公司 2024-11-05 CN claimed
CN-114324620-B Method for detecting p-trifluoromethoxy aniline and related impurities 鲁南制药集团股份有限公司 2024-10-11 CN claimed
CN-115322107-A Method for preparing p-trifluoromethoxyaniline through continuous hydrogenation 金凯(辽宁)生命科技股份有限公司 2022-11-11 CN claimed
CN-114524735-A Novel efficient production process of 4-trifluoromethoxyaniline 宁夏忠同生物科技有限公司 2022-05-24 CN claimed
CN-113856565-A Device and method for preparing p-trifluoromethoxyaniline through continuous catalytic hydrogenation 沈阳化工研究院有限公司 2021-12-31 CN claimed
CN-109796346-A A kind of method that nitro compound serialization adds hydrogen to prepare aromatic amine 大连理工大学 2019-05-24 CN claimed
WO-2016125185-A2 PROCESS FOR THE PREPARATION OF 4-SUBSTITUTED-1-(TRIFLUOROMETHOXY)BENZENE COMPOUNDS SRF LIMITED (IN) 2016-08-11 WO claimed
CN-102405084-B Process for separating aromatic compounds LANXESS DEUTSCHLAND GMBH (DE) 2015-09-30 CN claimed
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US claimed
EP-0225673-B1 PROCESS FOR THE PREPARATION OF ACYL UREAS SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1989-10-25 EP claimed
EP-0225673-A1 Process for the preparation of acyl ureas SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1987-06-16 EP claimed
US-4470930-A Preparation of nuclear chlorinated aromatic compounds OCCIDENTAL CHEMICAL CORPORATION (US) 1984-09-11 US claimed
JP-58079959-A None JP disclosed
CN-121913918-A Method for synthesizing p-nitro trifluoro-methoxybenzene by tubular reaction in supercritical fluid 西安近代化学研究所 2026-04-24 CN disclosed
US-4157344-A REACTING PHENOLS WITH A PERHALOMETHANE AND HYDROGEN FLUORIDE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1979-06-05 US disclosed
US-4153722-A ANTIINFLAMMATORY, A-PHENYL-N-PHENYLNITRONE WILLIAM H. RORER, INC. (US) 1979-05-08 US disclosed