SCHEMBL6940255

SCHEMBL6940255

Cc1cc(N)ccc1NCCO.Nc1ccc(N)c(CCO)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 2/20 0.37
CYP1A2 P05177 1/20 0.37
MAPT P10636 1/20 0.37
CYP2C9 P11712 1/20 0.37
SIGMAR1 Q99720 1/20 0.37
BRD4 O60885 1/20 0.36
RAD52 P43351 1/20 0.36
PDE10A Q9Y233 1/20 0.34
PRSS1 P07477 4/20 0.34
KMT2A Q03164 2/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 2/20 0.33
KDM4E B2RXH2 1/20 0.33
HSD17B10 Q99714 1/20 0.33
AR P10275 1/20 0.33
VDR P11473 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
CASP1 P29466 1/20 0.33
PIK3CA P42336 1/20 0.32
NQO2 P16083 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL33660 0.87 CYP2C19 (0.45) CYP2C19CYP1A2MAPTCYP2C9SIGMAR1
SCHEMBL29392615 0.87 CYP2C19 (0.45) CYP2C19CYP1A2MAPTCYP2C9SIGMAR1
SCHEMBL7774500 0.85 MAPT (0.37) CYP2C19CYP1A2MAPTCYP2C9SIGMAR1
Hydrochloric Acid SCHEMBL11438657 0.85 CYP2C19 (0.44) CYP2C19CYP1A2MAPTCYP2C9SIGMAR1
Water SCHEMBL11060635 0.85 CYP2C19 (0.44) CYP2C19CYP1A2MAPTCYP2C9SIGMAR1
SCHEMBL7865954 0.82 FCGR3B (0.36) CYP2C19PRSS1KMT2AALDH1A1KDM4E
Sulfuric Acid SCHEMBL4626210 0.80 MAPT (0.43) CYP2C19CYP1A2MAPTCYP2C9SIGMAR1
Sulfuric Acid SCHEMBL11060632 0.78 MAPT (0.42) CYP2C19CYP1A2MAPTCYP2C9SIGMAR1
SCHEMBL33767 0.78 PRKCI (0.38) MAPTRAD52KMT2AMEN1ALDH1A1
SCHEMBL29378444 0.78 PRKCI (0.38) MAPTRAD52KMT2AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0897713-B1 Hair-dye KPSS KAO GMBH (DE) 2003-04-02 EP disclosed
EP-0897713-A2 Hair-dye GOLDWELL GmbH (DE) 1999-02-24 EP disclosed