Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADA | P00813 | 8/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939100 | 0.87 | ADA (0.50) | ADATAAR1FAAHSCN9ATNKS | |
| SCHEMBL6133735 | 0.81 | ADA (0.59) | ADATAAR1FAAHSCN9ARBP4 | |
| Hydrochloric Acid SCHEMBL6133945 | 0.80 | ADA (0.58) | ADATAAR1FAAHSCN9ARBP4 | |
| SCHEMBL6938975 | 0.79 | ADA (0.52) | ADATAAR1FAAHSCN9AKDM5A | |
| SCHEMBL27455357 | 0.75 | TAAR1 (0.53) | TAAR1FAAHTNKSTNKS2PARP2 | |
| SCHEMBL6172589 | 0.74 | ADA (0.49) | ADARBP4KDM5AKDM4CKDM5B | |
| SCHEMBL5067382 | 0.73 | TAAR1 (0.56) | ADATAAR1FAAHTNKSTNKS2 | |
| SCHEMBL9714098 | 0.73 | LMNA (0.50) | ADARBP4KDM5AKDM4CKDM5B | |
| SCHEMBL6170502 | 0.71 | ADA (0.48) | ADARBP4KDM5AKDM4CKDM5B | |
| SCHEMBL6940305 | 0.70 | ADA (0.72) | ADATAAR1SCN9AJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596738-B1 | Inhibiting activity to adenosine deaminase (hereinafter described as ADA) An adenosine deaminase inhibiting agent comprising a compound of the formula (I): | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-07-22 | — | — | US | disclosed |
| EP-1161429-A2 | HETEROCYCLIC COMPOUNDS AS ADENOSINE DEAMINASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055155-A2 | HETEROCYCLIC COMPOUNDS AS ADENOSINE DEAMINASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-09-21 | — | — | WO | disclosed |