Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 10/20 | 0.45 |
| ▸ | KDM1A | O60341 | 10/20 | 0.45 |
| ▸ | MAOA | P21397 | 8/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.45 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.45 |
| ▸ | HTR2C | P28335 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28135209 | 1.00 | MAOB (0.45) | MAOBKDM1AMAOACYP2C19CYP2B6 | |
| SCHEMBL12242249 | 1.00 | MAOB (0.45) | MAOBKDM1AMAOACYP2C19CYP2B6 | |
| SCHEMBL16267930 | 0.82 | ALDH1A1 (0.31) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL12242256 | 0.80 | KDM1A (0.48) | MAOBKDM1AMAOACYP2C19HTR2C | |
| SCHEMBL2655142 | 0.80 | KDM1A (0.48) | KDM1AHTR2CSLC6A2SLC6A3HTR2B | |
| SCHEMBL1524090 | 0.80 | KDM1A (0.48) | MAOBKDM1AMAOACYP2C19HTR2C | |
| SCHEMBL1524088 | 0.80 | KDM1A (0.48) | MAOBKDM1AMAOACYP2C19HTR2C | |
| SCHEMBL17718447 | 0.80 | ALDH1A1 (0.50) | CYP2C19HTR2CCYP1A2CYP2C9CYP3A4 | |
| SCHEMBL12860014 | 0.80 | KDM1A (0.48) | MAOBKDM1AMAOACYP2C19HTR2C | |
| SCHEMBL27233654 | 0.80 | ALDH1A1 (0.50) | CYP2C19HTR2CCYP1A2CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103958474-B | (hetero) arylcyclopropylamine compounds as LSD1 inhibitors | 奥莱松基因组股份有限公司 | 2017-03-08 | — | — | CN | disclosed |
| EP-1101756-B1 | Aminopyrrolidine derivatives, processes for their preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-03-19 | — | — | EP | disclosed |
| US-6300366-B1 | FOR THERAPY OF CARDIOVASCULAR DISEASES, ESPECIALLY ARTERIAL HYPERTENSION, ARRHYTHMIA | ADIR ET COMPAGNIE (FR) | 2001-10-09 | — | — | US | disclosed |
| EP-1101756-A1 | Aminopyrrolidine derivatives, processes for their preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-05-23 | — | — | EP | disclosed |