Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943172 | 0.99 | MAPT (0.49) | HPGDLMNAMAPTMAPK1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6941400 | 0.88 | HPGD (0.46) | HPGDLMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL6946004 | 0.86 | HPGD (0.47) | HPGDLMNAMAPTMAPK1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6944291 | 0.85 | POLB (0.55) | HPGDLMNAMAPK1SMN1; SMN2KMT2A | |
| Hydrochloric Acid SCHEMBL6939292 | 0.84 | HPGD (0.43) | HPGDLMNAMAPK1SMN1; SMN2NPSR1 | |
| Hydrochloric Acid SCHEMBL6941314 | 0.84 | HPGD (0.51) | HPGDLMNASMN1; SMN2KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL6942071 | 0.84 | HPGD (0.42) | HPGDLMNAMAPTMAPK1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6941826 | 0.83 | LMNA (0.39) | HPGDLMNAMAPTMAPK1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6572793 | 0.83 | KMT2A (0.47) | HPGDLMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL6941358 | 0.83 | POLB (0.56) | HPGDLMNAMAPK1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066022-B1 | COMPOSITIONS FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC COUPLER, NOVEL CATIONIC COUPLERS, THEIR USE FOR OXIDATION DYEING AND DYEING METHODS | OREAL (FR) | 2003-10-22 | — | — | EP | claimed |
| US-6544298-B1 | Dyeing human hair using coupler | L'OREAL (FR) | 2003-04-08 | — | — | US | claimed |
| US-6544298-B1 | Dyeing human hair using coupler | L'OREAL (FR) | 2003-04-08 | — | — | US | disclosed |