Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.63 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.62 |
| ▸ | IDH2 | P48735 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 4/20 | 0.55 |
| ▸ | BRAF | P15056 | 4/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.54 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | KIF11 | P52732 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943827 | 0.89 | ABCG2 (0.68) | TRPV1MEN1MAPTKMT2ALMNA | |
| SCHEMBL22225457 | 0.88 | TRPV1 (0.63) | TRPV1GRIK1RXFP1MEN1MAPT | |
| SCHEMBL8095636 | 0.87 | MAPK14 (0.69) | TRPV1GRIK1MEN1MAPTKMT2A | |
| SCHEMBL6943829 | 0.83 | RORC (0.52) | MEN1MAPTKMT2ALMNAABCG2 | |
| SCHEMBL17103677 | 0.82 | TRPV1 (0.72) | TRPV1GRIK1RXFP1MEN1MAPT | |
| SCHEMBL29572518 | 0.82 | TRPV1 (0.72) | TRPV1GRIK1RXFP1MEN1MAPT | |
| SCHEMBL8104822 | 0.82 | MAPT (0.65) | MEN1MAPTKMT2ALMNAKDR | |
| SCHEMBL18013182 | 0.81 | TRPV1 (0.72) | TRPV1GRIK1MEN1MAPTKMT2A | |
| SCHEMBL8104833 | 0.80 | P2RY1 (0.61) | MEN1MAPTKMT2ALMNAMAPK14 | |
| SCHEMBL7625685 | 0.80 | MAPT (0.57) | MEN1MAPTKMT2ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042278-B1 | 1,3-DISUBSTITUTED UREAS AS ACAT INHIBITORS, AND METHOD OF PREPARING THEREOF | SLOVAKOFARMA AS (SK) | 2003-03-05 | — | — | EP | disclosed |
| US-6444691-B1 | ANTICHOLESTEROL AGENTS | SOLVAKOFARMA, A.S. (SK) | 2002-09-03 | — | — | US | disclosed |
| EP-1042278-A1 | 1,3-DISUBSTITUTED UREAS AS ACAT INHIBITORS, AND METHOD OF PREPARING THEREOF | Slovakofarma, A.S. (SK) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999032437-A1 | 1,3-DISUBSTITUTED UREAS AS ACAT INHIBITORS, AND METHOD OF PREPARING THEREOF | SLOVAKOFARMA, A.S. (SK) | 1999-07-01 | — | — | WO | disclosed |