Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 6/20 | 0.59 |
| ▸ | HTR1B | P28222 | 5/20 | 0.59 |
| ▸ | HTR1A | P08908 | 7/20 | 0.53 |
| ▸ | HTR2C | P28335 | 4/20 | 0.53 |
| ▸ | GABRP | O00591 | 1/20 | 0.50 |
| ▸ | GABRD | O14764 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.50 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.50 |
| ▸ | GABRE | P78334 | 1/20 | 0.50 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.50 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.50 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.50 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943364 | 0.75 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2CGABRP | |
| SCHEMBL6945655 | 0.73 | HTR1A (0.60) | HTR1DHTR1BHTR1AHTR2CSLC6A4 | |
| SCHEMBL6945199 | 0.72 | HTR1D (0.72) | HTR1DHTR1BMPO | |
| SCHEMBL6945185 | 0.72 | HTR1D (0.64) | HTR1DHTR1BHTR1AHTR2CGABRP | |
| SCHEMBL27392904 | 0.71 | HTR1A (0.67) | HTR1DHTR1BHTR1AHTR2CSLC6A4 | |
| SCHEMBL6944315 | 0.71 | SLC6A4 (0.49) | HTR1DHTR1BHTR1AHTR2CSLC6A4 | |
| SCHEMBL7480405 | 0.70 | HTR2C (0.50) | HTR1DHTR1BHTR1AHTR2CGABRP | |
| SCHEMBL6936730 | 0.69 | HTR1D (0.79) | HTR1DHTR1BHTR1AMPO | |
| SCHEMBL6939216 | 0.69 | HTR1A (0.65) | HTR1DHTR1BHTR1AHTR2CSLC6A4 | |
| SCHEMBL8781600 | 0.68 | HTR1D (0.74) | HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | claimed |
| CN-1322725-A | Indole derivant | MERCK & CO INC (US) | 2001-11-21 | — | — | CN | claimed |
| CN-1228094-A | Palladium catalyzed indolization | MERCK & CO INC (US) | 1999-09-08 | — | — | CN | claimed |
| US-5808064-A | HYDROSILATION OF AN INDOLE AS CHEMICAL INTERMEDIATE | MERCK & CO., INC. (US) | 1998-09-15 | — | — | US | claimed |
| CN-1152920-A | Palladium-Catalyzed Ring Closure of Triazolyl Tryptamine | MERCK & CO INC (US) | 1997-06-25 | — | — | CN | claimed |
| US-5567824-A | CATALYZING THE CYCLIZATION IN PRESENCE OF A SOLVENT AND A PROTON ACCEPTOR | MERCK & CO., INC. (US) | 1996-10-22 | — | — | US | claimed |
| CN-1157390-C | Indole derivant | — | 2004-07-14 | — | — | CN | disclosed |
| EP-0763032-B1 | PALLADIUM CATALYZED RING CLOSURE OF TRIAZOLYL TRYPTAMINE | MERCK & CO INC (US) | 2003-10-15 | — | — | EP | disclosed |
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | disclosed |
| CN-1084751-C | Palladium catalyzed indolization | MERCK & CO INC (US) | 2002-05-15 | — | — | CN | disclosed |
| CN-1077104-C | Palladium-Catalyzed Ring Closure of Triazolyl Tryptamine | MERCK & CO INC (US) | 2002-01-02 | — | — | CN | disclosed |
| CN-1322725-A | Indole derivant | MERCK & CO INC (US) | 2001-11-21 | — | — | CN | disclosed |
| CN-1228094-A | Palladium catalyzed indolization | MERCK & CO INC (US) | 1999-09-08 | — | — | CN | disclosed |
| EP-0925302-A1 | PALLADIUM CATALYZED INDOLIZATION | Merck & Co., Inc. (US) | 1999-06-30 | — | — | EP | disclosed |
| US-5808064-A | HYDROSILATION OF AN INDOLE AS CHEMICAL INTERMEDIATE | MERCK & CO., INC. (US) | 1998-09-15 | — | — | US | disclosed |
| WO-1998006725-A1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO., INC. (US) | 1998-02-19 | — | — | WO | disclosed |
| CN-1152920-A | Palladium-Catalyzed Ring Closure of Triazolyl Tryptamine | MERCK & CO INC (US) | 1997-06-25 | — | — | CN | disclosed |
| US-5567824-A | CATALYZING THE CYCLIZATION IN PRESENCE OF A SOLVENT AND A PROTON ACCEPTOR | MERCK & CO., INC. (US) | 1996-10-22 | — | — | US | disclosed |