Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 1/20 | 0.61 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.61 |
| ▸ | CTSL | P07711 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | MMP1 | P03956 | 1/20 | 0.53 |
| ▸ | FCER2 | P06734 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.50 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.50 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | REN | P00797 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5967294 | 0.90 | PSMB8 (0.54) | PSMB8PSMB5CTSLPOLBMMP1 | |
| SCHEMBL15251753 | 0.88 | PSMB8 (0.64) | PSMB8PSMB5CTSLPOLBCNR2 | |
| SCHEMBL2368090 | 0.88 | PSMB8 (0.64) | PSMB8PSMB5CTSLPOLBCNR2 | |
| SCHEMBL2368096 | 0.88 | PSMB8 (0.64) | PSMB8PSMB5CTSLPOLBCNR2 | |
| SCHEMBL20950865 | 0.87 | ERAP2 (0.51) | PSMB8PSMB5CTSLMMP1FCER2 | |
| SCHEMBL20950866 | 0.87 | ERAP2 (0.51) | PSMB8PSMB5CTSLMMP1FCER2 | |
| SCHEMBL14647999 | 0.84 | POLB (0.56) | CTSLPOLBCNR2ALDH1A1MAPT | |
| SCHEMBL20952029 | 0.84 | KISS1R (0.54) | CTSL | |
| SCHEMBL20952030 | 0.84 | KISS1R (0.54) | CTSL | |
| SCHEMBL20877889 | 0.83 | SMN1; SMN2 (0.60) | PSMB5MMP1FCER2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6638937-B2 | As antihypertensive agents; for therapy of disorders related to renal, glomerular and mesangial cell function; therapy of endotoxemia or endotoxin shock as well as hemorrhagic shock; useful in alleviation of pain associated cancer | BRISTOL-MYERS SQUIBB CO. | 2003-10-28 | — | — | US | disclosed |