Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6941663 | 1.00 | RAB9A (0.62) | RAB9AMAPTMAPK1NPSR1KMT2A | |
| SCHEMBL28051063 | 0.78 | RAB9A (0.48) | RAB9AMAPTMAPK1NPSR1KMT2A | |
| SCHEMBL3176468 | 0.76 | KMT2A (0.59) | RAB9AMAPTNPSR1KMT2AMEN1 | |
| SCHEMBL31293729 | 0.74 | DDAH1 (0.51) | RAB9AMAPTMAPK1NPSR1KMT2A | |
| SCHEMBL8383277 | 0.74 | DDAH1 (0.51) | RAB9AMAPTMAPK1NPSR1KMT2A | |
| SCHEMBL10758194 | 0.74 | KMT2A (0.50) | RAB9AMAPTMAPK1NPSR1KMT2A | |
| SCHEMBL10758191 | 0.74 | KMT2A (0.50) | RAB9AMAPTMAPK1NPSR1KMT2A | |
| SCHEMBL3534983 | 0.73 | HDAC3 (0.72) | RAB9AMAPTKMT2AMEN1HPGD | |
| SCHEMBL3534981 | 0.73 | HDAC3 (0.72) | RAB9AMAPTKMT2AMEN1HPGD | |
| SCHEMBL9305001 | 0.73 | KMT2A (0.56) | RAB9AMAPTMAPK1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6642246-B1 | Potent ligands for nicotinic acetylcholine receptors (nAChRs). Alzheimer's disease, cognitive or attention disorders, anxiety, depression, smoking cessation, neuroprotection, schizophrenia, analgesia, Tourette's syndrome, and Parkinson's | ASTRAZENECA AB (SE) | 2003-11-04 | — | — | US | disclosed |
| EP-1235826-B1 | QUINUCLIDINE ACRYLAMIDES | ASTRAZENECA AB (SE) | 2003-09-03 | — | — | EP | disclosed |
| EP-1235826-A1 | QUINUCLIDINE ACRYLAMIDES | AstraZeneca AB (SE) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001029034-A1 | QUINUCLIDINE ACRYLAMIDES | ASTRAZENECA AB (SE) | 2001-04-26 | — | — | WO | disclosed |