Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.53 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939407 | 0.81 | P2RX7 (0.72) | EPHX2P2RX7 | |
| SCHEMBL6941160 | 0.80 | P2RX7 (0.67) | EPHX2P2RX7GPR55KMT2A | |
| Hydrochloric Acid SCHEMBL6943149 | 0.80 | P2RX7 (0.71) | EPHX2P2RX7 | |
| Hydrochloric Acid SCHEMBL6943145 | 0.75 | P2RX7 (0.71) | EPHX2P2RX7KMT2A | |
| SCHEMBL6941695 | 0.74 | P2RX7 (0.65) | P2RX7CA12CA9GPR55MEN1 | |
| SCHEMBL6567675 | 0.70 | P2RX7 (0.65) | EPHX2P2RX7CA12CA9GPR55 | |
| SCHEMBL31390721 | 0.70 | CNR2 (0.70) | EPHX2P2RX7CA12CA9GPR55 | |
| SCHEMBL4257611 | 0.70 | EPHX2 (1.00) | EPHX2 | |
| SCHEMBL27870154 | 0.69 | EPHX2 (0.77) | EPHX2 | |
| SCHEMBL22775754 | 0.69 | P2RX7 (0.63) | EPHX2P2RX7CA12CA9GPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036058-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2003-03-12 | — | — | EP | claimed |
| US-6242470-B1 | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS, ANTIALLERGENS; IRRITABLE BOWEL SYNDROME; AMIDATION | ASTRAZENECA AB (SE) | 2001-06-05 | — | — | US | claimed |
| EP-1036058-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2003-03-12 | — | — | EP | disclosed |
| US-6242470-B1 | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS, ANTIALLERGENS; IRRITABLE BOWEL SYNDROME; AMIDATION | ASTRAZENECA AB (SE) | 2001-06-05 | — | — | US | disclosed |