Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.65 |
| ▸ | MMP3 | P08254 | 4/20 | 0.44 |
| ▸ | MMP2 | P08253 | 11/20 | 0.42 |
| ▸ | MMP9 | P14780 | 8/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 5/20 | 0.40 |
| ▸ | MMP14 | P50281 | 2/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 3/20 | 0.39 |
| ▸ | MMP1 | P03956 | 2/20 | 0.39 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942387 | 0.82 | ADAM17 (0.71) | ADAM17MMP3MMP2MMP9MMP13 | |
| SCHEMBL6945579 | 0.81 | ADAM17 (0.62) | ADAM17MMP3MMP2MMP9MMP13 | |
| SCHEMBL6945567 | 0.81 | ADAM17 (0.44) | ADAM17MMP3MMP2MMP9HPGD | |
| SCHEMBL6942613 | 0.81 | ADAM17 (0.68) | ADAM17MMP3MMP2MMP9MMP13 | |
| SCHEMBL6940244 | 0.80 | ADAM17 (0.65) | ADAM17MMP3MMP2MMP9MMP13 | |
| SCHEMBL4481744 | 0.79 | ADAM17 (1.00) | ADAM17MMP3MMP2MMP9MMP13 | |
| SCHEMBL13274076 | 0.79 | ADAM17 (1.00) | ADAM17MMP3MMP2MMP9MMP13 | |
| SCHEMBL6813847 | 0.79 | ADAM17 (1.00) | ADAM17MMP3MMP2MMP9MMP13 | |
| SCHEMBL6813844 | 0.79 | ADAM17 (1.00) | ADAM17MMP3MMP2MMP9MMP13 | |
| SCHEMBL3500092 | 0.79 | ADAM17 (1.00) | ADAM17MMP3MMP2MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |