Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 1.00 |
| ▸ | MMP2 | P08253 | 16/20 | 0.42 |
| ▸ | MMP3 | P08254 | 12/20 | 0.42 |
| ▸ | MMP7 | P09237 | 11/20 | 0.42 |
| ▸ | MMP1 | P03956 | 11/20 | 0.41 |
| ▸ | MMP9 | P14780 | 4/20 | 0.41 |
| ▸ | MMP8 | P22894 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | FCER2 | P06734 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13274076 | 1.00 | ADAM17 (1.00) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6813847 | 1.00 | ADAM17 (1.00) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL4481744 | 1.00 | ADAM17 (1.00) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL3500092 | 1.00 | ADAM17 (1.00) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6942162 | 0.92 | ADAM17 (0.85) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6946003 | 0.92 | ADAM17 (0.85) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6946135 | 0.92 | ADAM17 (0.85) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6946832 | 0.92 | ADAM17 (0.85) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6942514 | 0.92 | ADAM17 (0.85) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6941769 | 0.92 | ADAM17 (0.85) | ADAM17MMP2MMP3MMP7MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011076854-A1 | CLEAVAGE OF β-AMYLOID PRECURSOR PROTEIN | PROBIODRUG AG (DE) | 2011-06-30 | — | — | WO | disclosed |
| US-20110152341-A1 | CLEAVAGE OF B-AMYLOID PRECURSOR PROTEIN | PROBIODRUG AG (DE) | 2011-06-23 | — | — | US | disclosed |
| US-20110152341-A1 | CLEAVAGE OF B-AMYLOID PRECURSOR PROTEIN | PROBIODRUG AG (DE) | 2011-06-23 | — | — | US | disclosed |
| WO-2004110457-A1 | MATRIX METALLOPROTEINASES INHIBITORS FOR THE STIMULATION AND PROTECTION OF BONE MARROW STEM CELLS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152341-A1 | CLEAVAGE OF B-AMYLOID PRECURSOR PROTEIN | MEP1B, MEP1A, APP | ADAM17 36/4885MMP2 1555/4885MMP3 1361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.