Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 3/20 | 0.39 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.32 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
| ▸ | MASP2 | O00187 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987205 | 0.87 | ADAM17 (0.37) | ADAM17CTSC | |
| SCHEMBL7812777 | 0.86 | ADAM17 (0.36) | ADAM17CTSC | |
| Hydrochloric Acid SCHEMBL6985210 | 0.86 | ADAM17 (0.36) | ADAM17CTSCHTR2AMASP2 | |
| Hydrochloric Acid SCHEMBL7805704 | 0.86 | ADAM17 (0.36) | ADAM17CTSCHTR2AMASP2 | |
| SCHEMBL6983517 | 0.85 | ADAM17 (0.37) | ADAM17CTSC | |
| SCHEMBL6986074 | 0.82 | ADAM17 (0.34) | ADAM17 | |
| SCHEMBL7812945 | 0.82 | ADAM17 (0.34) | ADAM17MMP1MMP9 | |
| SCHEMBL6982348 | 0.82 | MMP1 (0.38) | ADAM17MMP1MMP2MMP3GRIK1 | |
| SCHEMBL6984201 | 0.82 | ADAM17 (0.37) | ADAM17CTSC | |
| SCHEMBL6985245 | 0.81 | ADAM17 (0.42) | ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |