Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 3/20 | 0.62 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 12/20 | 0.38 |
| ▸ | MMP3 | P08254 | 9/20 | 0.38 |
| ▸ | MMP7 | P09237 | 8/20 | 0.38 |
| ▸ | MMP1 | P03956 | 8/20 | 0.38 |
| ▸ | MMP9 | P14780 | 5/20 | 0.38 |
| ▸ | MMP14 | P50281 | 3/20 | 0.38 |
| ▸ | MMP8 | P22894 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 3/20 | 0.37 |
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | LAP3 | P28838 | 1/20 | 0.37 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.37 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.37 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.37 |
| ▸ | MMP10 | P09238 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980527 | 0.91 | ADAM17 (0.61) | ADAM17APPMMP2MMP3MMP7 | |
| SCHEMBL6982408 | 0.91 | ADAM17 (0.61) | ADAM17APPMMP2MMP3MMP7 | |
| Hydrochloric Acid SCHEMBL6984184 | 0.90 | ADAM17 (0.60) | ADAM17APPMMP2MMP3MMP7 | |
| Hydrochloric Acid SCHEMBL6983130 | 0.89 | ADAM17 (0.56) | ADAM17APPMMP2MMP3MMP7 | |
| Hydrochloric Acid SCHEMBL6984700 | 0.88 | ADAM17 (0.61) | ADAM17APPMMP2MMP3MMP7 | |
| SCHEMBL6984415 | 0.88 | ADAM17 (0.59) | ADAM17APPMMP2MMP3MMP7 | |
| Hydrochloric Acid SCHEMBL6984773 | 0.86 | ADAM17 (0.57) | ADAM17APPMMP2MMP3MMP7 | |
| Hydrochloric Acid SCHEMBL6984250 | 0.86 | ADAM17 (0.57) | ADAM17APPMMP2MMP3MMP7 | |
| SCHEMBL6979784 | 0.86 | ADAM17 (0.59) | ADAM17APPMMP2MMP3MMP7 | |
| Hydrochloric Acid SCHEMBL6983264 | 0.86 | ADAM17 (0.61) | ADAM17APPMMP2MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |