Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 3/20 | 0.59 |
| ▸ | MMP3 | P08254 | 13/20 | 0.38 |
| ▸ | MMP1 | P03956 | 12/20 | 0.38 |
| ▸ | MMP9 | P14780 | 4/20 | 0.38 |
| ▸ | MMP14 | P50281 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 14/20 | 0.36 |
| ▸ | MMP7 | P09237 | 10/20 | 0.36 |
| ▸ | MMP8 | P22894 | 3/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | FCER2 | P06734 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982408 | 0.95 | ADAM17 (0.61) | ADAM17MMP3MMP1MMP9MMP14 | |
| SCHEMBL6942318 | 0.88 | ADAM17 (0.62) | ADAM17MMP3MMP1MMP9MMP14 | |
| SCHEMBL6980527 | 0.86 | ADAM17 (0.61) | ADAM17MMP3MMP1MMP9MMP14 | |
| Hydrochloric Acid SCHEMBL6984184 | 0.85 | ADAM17 (0.60) | ADAM17MMP3MMP1MMP9MMP14 | |
| Hydrochloric Acid SCHEMBL6984700 | 0.85 | ADAM17 (0.61) | ADAM17MMP3MMP1MMP9MMP14 | |
| SCHEMBL6985048 | 0.85 | ADAM17 (0.59) | ADAM17MMP3MMP1MMP9MMP14 | |
| SCHEMBL6979784 | 0.85 | ADAM17 (0.59) | ADAM17MMP3MMP1MMP9MMP14 | |
| Hydrochloric Acid SCHEMBL6983264 | 0.83 | ADAM17 (0.61) | ADAM17MMP3MMP1MMP9MMP14 | |
| Hydrochloric Acid SCHEMBL6983130 | 0.83 | ADAM17 (0.56) | ADAM17MMP3MMP1MMP9MMP14 | |
| SCHEMBL6942575 | 0.82 | ADAM17 (0.73) | ADAM17MMP3MMP1MMP9MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |