Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 6/20 | 0.40 |
| ▸ | MMP3 | P08254 | 6/20 | 0.40 |
| ▸ | MMP1 | P03956 | 5/20 | 0.40 |
| ▸ | MMP8 | P22894 | 4/20 | 0.40 |
| ▸ | MMP13 | P45452 | 3/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MMP7 | P09237 | 3/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942356 | 1.00 | ADAM17 (0.46) | ADAM17GAAMMP2MMP3MMP1 | |
| SCHEMBL27522457 | 1.00 | ADAM17 (0.46) | ADAM17GAAMMP2MMP3MMP1 | |
| SCHEMBL6945099 | 0.87 | ADAM17 (0.58) | ADAM17GAAMMP2MMP3MMP1 | |
| SCHEMBL6945094 | 0.87 | ADAM17 (0.58) | ADAM17GAAMMP2MMP3MMP1 | |
| SCHEMBL6945072 | 0.87 | ADAM17 (0.58) | ADAM17GAAMMP2MMP3MMP1 | |
| SCHEMBL6946881 | 0.87 | ADAM17 (0.44) | ADAM17GAAMMP2MMP3MMP1 | |
| SCHEMBL6946872 | 0.87 | ADAM17 (0.44) | ADAM17GAAMMP2MMP3MMP1 | |
| SCHEMBL6946875 | 0.87 | ADAM17 (0.44) | ADAM17GAAMMP2MMP3MMP1 | |
| SCHEMBL6946879 | 0.87 | ADAM17 (0.44) | ADAM17GAAMMP2MMP3MMP1 | |
| SCHEMBL6220231 | 0.85 | ADAM17 (0.43) | ADAM17GAAMMP2MMP3MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |