Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | FCER2 | P06734 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944673 | 0.97 | ADAM17 (0.46) | ADAM17GRIK1GRIK2HPGDMAPT | |
| SCHEMBL6947352 | 0.93 | ADAM17 (0.51) | ADAM17P2RX3ALDH1A1TGFBR1KMT2A | |
| SCHEMBL6942385 | 0.90 | ADAM17 (0.45) | ADAM17SMN1; SMN2FCER2P2RX3ALDH1A1 | |
| SCHEMBL6945960 | 0.89 | ADAM17 (0.51) | ADAM17P2RX3TGFBR1 | |
| SCHEMBL6943250 | 0.89 | ADAM17 (0.50) | ADAM17GRIK1GRIK2HPGDSMN1; SMN2 | |
| SCHEMBL6940024 | 0.88 | ADAM17 (0.48) | ADAM17GRIK1GRIK2SMN1; SMN2MMP1 | |
| SCHEMBL6943306 | 0.87 | ADAM17 (0.45) | ADAM17MMP1P2RX3TGFBR1 | |
| SCHEMBL6940527 | 0.86 | ADAM17 (0.46) | ADAM17P2RX3ALDH1A1TGFBR1 | |
| SCHEMBL6942478 | 0.85 | ADAM17 (0.41) | ADAM17MMP1P2RX3ALDH1A1TGFBR1 | |
| SCHEMBL6946107 | 0.85 | ADAM17 (0.38) | ADAM17MMP1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |