Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947352 | 0.94 | ADAM17 (0.51) | ADAM17TGFBR1MMP2GAAP2RX3 | |
| SCHEMBL6945960 | 0.90 | ADAM17 (0.51) | ADAM17TGFBR1MMP2P2RX3 | |
| SCHEMBL6940024 | 0.88 | ADAM17 (0.48) | ADAM17MMP1MMP2MMP3POLB | |
| SCHEMBL6942385 | 0.88 | ADAM17 (0.45) | ADAM17TGFBR1P2RX3POLB | |
| SCHEMBL6944673 | 0.87 | ADAM17 (0.46) | ADAM17MMP1P2RX3 | |
| SCHEMBL6942441 | 0.87 | ADAM17 (0.45) | ADAM17TGFBR1MMP1P2RX3 | |
| SCHEMBL6940527 | 0.87 | ADAM17 (0.46) | ADAM17TGFBR1MMP2GAAP2RX3 | |
| SCHEMBL6943951 | 0.86 | ADAM17 (0.51) | ADAM17CHRNB2CHRNA4TGFBR1MMP1 | |
| SCHEMBL6946852 | 0.86 | ADAM17 (0.40) | ADAM17TGFBR1MMP2MMP3MMP7 | |
| SCHEMBL6946888 | 0.86 | ADAM17 (0.48) | ADAM17TGFBR1MMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |