SCHEMBL6942456

SCHEMBL6942456

O=C(c1cccnc1)c1ccccc1[N+](=O)[O-]

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 3/20 0.63
MAPT P10636 5/20 0.60
KMT2A Q03164 2/20 0.60
CYP1A2 P05177 1/20 0.60
CYP2C9 P11712 1/20 0.60
KDM4E B2RXH2 1/20 0.51
LMNA P02545 4/20 0.51
GAA P10253 2/20 0.50
NCOA1 Q15788 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
NCOA3 Q9Y6Q9 1/20 0.50
ALDH1A1 P00352 4/20 0.49
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
CTSD P07339 1/20 0.46
MEN1 O00255 1/20 0.46
HSP90AA1 P07900 1/20 0.46
APP P05067 1/20 0.46
HCAR3 P49019 1/20 0.46
HCAR2 Q8TDS4 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyridine SCHEMBL27540706 0.86 ALDH1A1 (0.56) HTTMAPTKMT2ACYP1A2CYP2C9
Pyrimidine SCHEMBL27461454 0.86 ALDH1A1 (0.56) HTTMAPTKMT2ACYP1A2CYP2C9
SCHEMBL6644387 0.83 SMN1; SMN2 (0.61) HTTMAPTKMT2ACYP1A2CYP2C9
SCHEMBL411359 0.82 ALDH1A1 (0.59) HTTMAPTKDM4EGAAALDH1A1
SCHEMBL27637513 0.82 ALDH1A1 (0.59) HTTMAPTKDM4EGAAALDH1A1
SCHEMBL10638513 0.81 KMT2A (0.53) HTTMAPTKMT2ACYP1A2CYP2C9
Carbamic Acid SCHEMBL27651915 0.81 CTSD (0.56) HTTMAPTKDM4EGAAALDH1A1
SCHEMBL28783981 0.80 ALDH1A1 (0.58) HTTMAPTKDM4EGAAALDH1A1
Hydrogen Sulfide SCHEMBL28794532 0.80 ALDH1A1 (0.58) HTTMAPTKDM4EGAAALDH1A1
Water SCHEMBL4951772 0.80 ALDH1A1 (0.58) HTTMAPTKMT2ACYP2C9KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1342719-A1 Benzodiazepine derivatives useful as CCK-Receptor Antagonists YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 2003-09-10 EP disclosed
EP-0628033-B1 BENZODIAZEPIN DERIVATIVES USEFUL AS CCK-RECEPTOR ANTAGONISTS YAMANOUCHI PHARMA CO LTD (JP) 2003-07-23 EP disclosed
CN-1051079-C Benzodiazepine * derivatives, process for their preparation and pharmaceutical compositions containing them YAMANOUCHI PHARMA CO LTD (JP) 2000-04-05 CN disclosed
US-5962451-A GASTROINTESTINAL DISORDERS; ANTIULCER AGENT; ANTICANCER AGENTS; SIDE-EFFECT REDUCTION FERRING BV (NL) 1999-10-05 US disclosed
US-5688943-A CHOLECYSTOKININ ANTAGONIST; ANTIULCER AGENTS; PSYCHOLOGICAL DRUGS; ANXIOLYTIC AGENTS; CONTROLLING APPETITE YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1997-11-18 US disclosed
EP-0628033-A1 BENZODIAZEPIN DERIVATIVES USEFUL AS CCK-RECEPTOR ANTAGONISTS YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1994-12-14 EP disclosed
WO-1993016999-A1 BENZODIAZEPIN DERIVATIVES USEFUL AS CCK-RECEPTOR ANTAGONISTS YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1993-09-02 WO disclosed
CN-1075717-A Benzodiazepine * derivatives YAMANOUCHI PHARMA CO LTD (JP) 1993-09-01 CN disclosed