Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 1/20 | 0.58 |
| ▸ | CTSL | P07711 | 1/20 | 0.58 |
| ▸ | TNKS | O95271 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11659575 | 0.84 | HPGD (0.56) | CTSVCTSLTNKSKDM4EKMT2A | |
| SCHEMBL30234925 | 0.78 | TNKS (0.68) | CTSVCTSLTNKSKDM4EKMT2A | |
| SCHEMBL695264 | 0.75 | CTSV (0.49) | CTSVCTSLTNKSKDM4EKMT2A | |
| SCHEMBL28251861 | 0.74 | DAO (0.53) | KDM4EKMT2AHPGDALDH1A1DAO | |
| SCHEMBL5074066 | 0.74 | CTSV (0.55) | CTSVCTSLTNKSKDM4EKMT2A | |
| SCHEMBL6001399 | 0.73 | CTSV (1.00) | CTSVCTSLKDM4EKMT2APDE10A | |
| SCHEMBL29411879 | 0.73 | CTSV (1.00) | CTSVCTSLKDM4EKMT2APDE10A | |
| SCHEMBL7495171 | 0.73 | DAO (0.45) | KMT2ADAOCNR2MEN1 | |
| SCHEMBL29496847 | 0.72 | RAB9A (0.71) | CTSVCTSLKDM4EKMT2AHPGD | |
| SCHEMBL2061664 | 0.72 | RAB9A (0.71) | CTSVCTSLKDM4EKMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421825-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | claimed |
| WO-2010124108-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | claimed |