Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 2/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6511961 | 0.85 | NR1H3 (0.55) | NR1H3MEN1KMT2AEPHX1OPRM1 | |
| SCHEMBL6943105 | 0.76 | NR1H3 (0.64) | NR1H3MEN1KMT2ANR1I2MAPT | |
| SCHEMBL6513596 | 0.73 | NR1H3 (0.76) | NR1H3MEN1KMT2AHTTLMNA | |
| SCHEMBL6510840 | 0.68 | NR1H3 (0.64) | NR1H3MEN1KMT2AHTTNR1I2 | |
| SCHEMBL8565479 | 0.64 | EPHX1 (0.48) | MEN1KMT2AEPHX1HDAC6TSHR | |
| SCHEMBL6510846 | 0.62 | NR1H3 (0.71) | NR1H3MEN1KMT2ANR1I2MAPT | |
| SCHEMBL4829920 | 0.62 | LMNA (0.67) | MEN1KMT2AHTTCHRM2CYP3A4 | |
| SCHEMBL22592517 | 0.61 | MEN1 (0.47) | MEN1KMT2ACHRM2CYP3A4LMNA | |
| SCHEMBL8007179 | 0.60 | KMT2A (0.67) | MEN1KMT2ACYP3A4LMNAMAPT | |
| SCHEMBL7509809 | 0.60 | SNCA (0.51) | MEN1KMT2AHTTLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318976-A2 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LIMITED (GB) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024632-A2 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LIMITED (GB) | 2002-03-28 | — | — | WO | disclosed |