Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 7/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | HNF4A | P41235 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 5/20 | 0.35 |
| ▸ | RARA | P10276 | 2/20 | 0.35 |
| ▸ | RARG | P13631 | 2/20 | 0.35 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944154 | 0.92 | RARB (0.39) | CYP26A1CYP3A4CYP26B1TP53TSHR | |
| SCHEMBL6144565 | 0.91 | CYP26A1 (0.46) | CYP26A1CYP3A4CYP26B1PLA2G4BRXRA | |
| SCHEMBL4847037 | 0.84 | CYP26A1 (0.46) | CYP26A1CYP3A4CYP26B1PLA2G4BRXRA | |
| SCHEMBL6146889 | 0.83 | RARA (0.38) | CYP26A1CYP3A4CYP26B1TSHRRARB | |
| SCHEMBL4842332 | 0.81 | CYP26A1 (0.55) | CYP26A1CYP3A4CYP26B1PLA2G4BRXRA | |
| SCHEMBL6146459 | 0.78 | CYP26A1 (0.71) | CYP26A1CYP3A4CYP26B1PLA2G4BRXRA | |
| SCHEMBL6144279 | 0.78 | CYP26A1 (0.71) | CYP26A1CYP3A4CYP26B1PLA2G4BRXRA | |
| SCHEMBL6144103 | 0.78 | CYP26A1 (0.71) | CYP26A1CYP3A4CYP26B1PLA2G4BRXRA | |
| SCHEMBL4847717 | 0.76 | CYP3A4 (0.38) | CYP26A1CYP3A4CYP26B1RXRAHNF4A | |
| SCHEMBL6144179 | 0.76 | CYP26A1 (0.50) | CYP26A1CYP3A4CYP26B1PLA2G4BRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280757-A2 | NEW GAMMA SELECTIVE RETINOIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-02-05 | — | — | EP | claimed |
| WO-2001083438-A2 | NEW GAMMA SELECTIVE RETINOIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-08 | — | — | WO | claimed |
| EP-1280757-A2 | NEW GAMMA SELECTIVE RETINOIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-02-05 | — | — | EP | disclosed |
| WO-2001083438-A2 | NEW GAMMA SELECTIVE RETINOIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-08 | — | — | WO | disclosed |