Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 2/20 | 0.39 |
| ▸ | RARG | P13631 | 2/20 | 0.39 |
| ▸ | RARA | P10276 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.35 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942679 | 0.92 | CYP26A1 (0.44) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL6146889 | 0.91 | RARA (0.38) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL4847717 | 0.85 | CYP3A4 (0.38) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL6144565 | 0.83 | CYP26A1 (0.46) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL4846989 | 0.82 | CYP3A4 (0.46) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL6148260 | 0.78 | CYP3A4 (0.57) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL6148261 | 0.78 | CYP3A4 (0.57) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL6146272 | 0.77 | CYP3A4 (0.40) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL4847037 | 0.76 | CYP26A1 (0.46) | RARBCYP3A4CYP26A1CYP26B1TSHR | |
| SCHEMBL6145974 | 0.74 | RARB (0.43) | RARBRARGRARACYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280757-A2 | NEW GAMMA SELECTIVE RETINOIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-02-05 | — | — | EP | disclosed |
| WO-2001083438-A2 | NEW GAMMA SELECTIVE RETINOIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-08 | — | — | WO | disclosed |