Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 2/20 | 0.35 |
| ▸ | FCER2 | P06734 | 1/20 | 0.35 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | GLO1 | Q04760 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940960 | 0.85 | TP53 (0.31) | ALDH1A1NPC1RAB9ASMN1; SMN2ALOX15 | |
| SCHEMBL6945653 | 0.80 | ADAM17 (0.45) | ADAM17MMP1FCER2LMNAMMP2 | |
| SCHEMBL8107345 | 0.78 | ADAM17 (0.41) | ADAM17MMP1ALDH1A1LMNAMMP2 | |
| SCHEMBL6945777 | 0.78 | ADAM17 (0.47) | ADAM17MMP1FCER2MMP2MMP3 | |
| SCHEMBL6941579 | 0.77 | ADAM17 (0.46) | ADAM17MMP1FCER2MMP2MMP3 | |
| SCHEMBL6947691 | 0.77 | ADAM17 (0.40) | ADAM17MMP1MMP2MMP3MMP7 | |
| SCHEMBL4481740 | 0.76 | ADAM17 (0.46) | ADAM17MMP1FCER2MMP2MMP3 | |
| SCHEMBL6942610 | 0.76 | ADAM17 (0.46) | ADAM17MMP1FCER2MMP2MMP3 | |
| SCHEMBL6939409 | 0.76 | ADAM17 (0.46) | ADAM17MMP1FCER2MMP2MMP3 | |
| SCHEMBL6941767 | 0.76 | ADAM17 (0.46) | ADAM17MMP1FCER2MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |