Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 3/20 | 0.41 |
| ▸ | MMP1 | P03956 | 9/20 | 0.38 |
| ▸ | MMP9 | P14780 | 4/20 | 0.38 |
| ▸ | MMP13 | P45452 | 4/20 | 0.38 |
| ▸ | MMP2 | P08253 | 6/20 | 0.37 |
| ▸ | MMP3 | P08254 | 6/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945653 | 0.90 | ADAM17 (0.45) | ADAM17MMP1MMP9MMP13MMP2 | |
| SCHEMBL6940018 | 0.85 | MMP2 (0.33) | ADAM17MMP1MMP9MMP13MMP2 | |
| SCHEMBL6945116 | 0.84 | ADAM17 (0.40) | ADAM17MMP1MMP9MMP13MMP2 | |
| SCHEMBL6945777 | 0.80 | ADAM17 (0.47) | ADAM17MMP1MMP9MMP13MMP2 | |
| SCHEMBL6941579 | 0.80 | ADAM17 (0.46) | ADAM17MMP1MMP9MMP13MMP2 | |
| SCHEMBL6947691 | 0.79 | ADAM17 (0.40) | ADAM17MMP1MMP2MMP3EGFR | |
| SCHEMBL4481740 | 0.79 | ADAM17 (0.46) | ADAM17MMP1MMP9MMP13MMP2 | |
| SCHEMBL6942610 | 0.79 | ADAM17 (0.46) | ADAM17MMP1MMP9MMP13MMP2 | |
| SCHEMBL6939409 | 0.79 | ADAM17 (0.46) | ADAM17MMP1MMP9MMP13MMP2 | |
| SCHEMBL6941767 | 0.79 | ADAM17 (0.46) | ADAM17MMP1MMP9MMP13MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |