Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6941691 | 0.99 | POLB (0.44) | POLBALDH1A1KMT2AMAPK1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL7636184 | 0.81 | MEN1 (0.41) | POLBALDH1A1KMT2AMAPK1HSP90AA1 | |
| Hydrochloric Acid SCHEMBL6944233 | 0.78 | TDP1 (0.45) | ALDH1A1KMT2AHSP90AA1LMNA | |
| Hydrochloric Acid SCHEMBL6573230 | 0.77 | HSP90AA1 (0.42) | POLBALDH1A1KMT2AMAPK1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL7073691 | 0.77 | KMT2A (0.52) | POLBALDH1A1KMT2AHSP90AA1LMNA | |
| Hydrochloric Acid SCHEMBL6943286 | 0.77 | POLB (0.45) | POLBALDH1A1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL6939386 | 0.76 | TDP1 (0.46) | POLBALDH1A1KMT2AHSP90AA1HSD17B10 | |
| SCHEMBL6946228 | 0.76 | KDM4E (0.41) | POLBALDH1A1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL6940581 | 0.76 | HSP90AA1 (0.50) | POLBALDH1A1KMT2AL3MBTL1HSP90AA1 | |
| SCHEMBL6945414 | 0.75 | POLB (0.43) | POLBALDH1A1KMT2AMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066022-B1 | COMPOSITIONS FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC COUPLER, NOVEL CATIONIC COUPLERS, THEIR USE FOR OXIDATION DYEING AND DYEING METHODS | OREAL (FR) | 2003-10-22 | — | — | EP | claimed |
| US-6544298-B1 | Dyeing human hair using coupler | L'OREAL (FR) | 2003-04-08 | — | — | US | claimed |
| US-6537329-B1 | Intense colorations with a wide range of colours, excellent colorfastness | L'OREAL S.A. (FR) | 2003-03-25 | — | — | US | claimed |
| US-6544298-B1 | Dyeing human hair using coupler | L'OREAL (FR) | 2003-04-08 | — | — | US | disclosed |
| US-6537329-B1 | Intense colorations with a wide range of colours, excellent colorfastness | L'OREAL S.A. (FR) | 2003-03-25 | — | — | US | disclosed |