Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946228 | 0.98 | KDM4E (0.41) | HSP90AA1LMNAKMT2APABPC1KDM4E | |
| Hydrochloric Acid SCHEMBL6939400 | 0.84 | LMNA (0.38) | HSP90AA1LMNAKMT2APABPC1KDM4E | |
| SCHEMBL6944670 | 0.82 | RAB9A (0.38) | HSP90AA1LMNAKMT2APABPC1KDM4E | |
| Hydrochloric Acid SCHEMBL6574934 | 0.78 | MEN1 (0.46) | HSP90AA1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL6944437 | 0.78 | HSP90AA1 (0.47) | HSP90AA1KMT2APABPC1KDM4ERAB9A | |
| Hydrochloric Acid SCHEMBL6941749 | 0.78 | LMNA (0.47) | HSP90AA1LMNAKMT2APABPC1KDM4E | |
| Hydrochloric Acid SCHEMBL6942966 | 0.77 | POLB (0.46) | HSP90AA1LMNAKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL6573856 | 0.76 | MEN1 (0.47) | HSP90AA1LMNAKMT2AMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6944233 | 0.76 | TDP1 (0.45) | HSP90AA1LMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL6944450 | 0.76 | LMNA (0.44) | HSP90AA1LMNAKMT2APABPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066264-B1 | NOVEL CATIONIC 2-SULPHONYLAMINOPHENOLS, THEIR USE AS COUPLERS FOR OXIDATION DYEING, COMPOSITIONS CONTAINING THEM AND DYEING METHODS | OREAL (FR) | 2004-11-17 | — | — | EP | claimed |
| EP-1066022-B1 | COMPOSITIONS FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC COUPLER, NOVEL CATIONIC COUPLERS, THEIR USE FOR OXIDATION DYEING AND DYEING METHODS | OREAL (FR) | 2003-10-22 | — | — | EP | claimed |
| US-6544298-B1 | Dyeing human hair using coupler | L'OREAL (FR) | 2003-04-08 | — | — | US | claimed |
| US-6537329-B1 | Intense colorations with a wide range of colours, excellent colorfastness | L'OREAL S.A. (FR) | 2003-03-25 | — | — | US | claimed |
| US-6544298-B1 | Dyeing human hair using coupler | L'OREAL (FR) | 2003-04-08 | — | — | US | disclosed |
| US-6537329-B1 | Intense colorations with a wide range of colours, excellent colorfastness | L'OREAL S.A. (FR) | 2003-03-25 | — | — | US | disclosed |