SCHEMBL6942973

SCHEMBL6942973

CC(CN)CC(=O)[C@H](C)C(=O)O

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GABRR1 P24046 4/20 0.38
CACNA2D1 P54289 2/20 0.38
CACNB3 P54284 1/20 0.38
CACNA1C Q13936 1/20 0.38
PGR P06401 1/20 0.38
ADRA1A P35348 1/20 0.38
HTR2B P41595 1/20 0.38
CACNA2D2 Q9NY47 1/20 0.38
GABBR2 O75899 1/20 0.37
GABBR1 Q9UBS5 1/20 0.37
CYP1A2 P05177 1/20 0.37
LMNA P02545 1/20 0.34
SLC7A5 Q01650 1/20 0.33
CPB1 P15086 1/20 0.33
CPB2 Q96IY4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7538378 0.80
SCHEMBL28609539 0.80
Hydrochloric Acid SCHEMBL28341271 0.78 GABRR1 (0.42) GABRR1CACNA2D1CACNB3CACNA1CLMNA
SCHEMBL27687487 0.76 TP53 (0.35) GABRR1CACNA2D1CACNB3CACNA1CPGR
SCHEMBL23113877 0.75
SCHEMBL2430808 0.75 ALDH1A1 (0.46) LMNASLC7A5
SCHEMBL1118765 0.75
SCHEMBL1118762 0.75
Hydrochloric Acid SCHEMBL4740730 0.73
SCHEMBL9579834 0.73 GABRR1 (0.42) GABRR1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0956033-B1 TOTAL SYNTHESIS OF THE AMINO HIP ANALOGUE OF DIDEMNIN A UNIV ILLINOIS (US) 2003-07-23 EP claimed
EP-0956033-A4 TOTAL SYNTHESIS OF THE AMINO HIP ANALOGUE OF DIDEMNIN A UNIV ILLINOIS (US) 2000-06-21 EP claimed
EP-0956033-A1 TOTAL SYNTHESIS OF THE AMINO HIP ANALOGUE OF DIDEMNIN A THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 1999-11-17 EP claimed
WO-1998017302-A1 TOTAL SYNTHESIS OF THE AMINO HIP ANALOGUE OF DIDEMNIN A THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 1998-04-30 WO claimed
EP-0956033-B1 TOTAL SYNTHESIS OF THE AMINO HIP ANALOGUE OF DIDEMNIN A UNIV ILLINOIS (US) 2003-07-23 EP disclosed
US-6380156-B1 HAVING ANTIVIRAL, ANTITUMOR, AND IMMUNOSUPPRESSIVE ACTIVITIES THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLNOIS 2002-04-30 US disclosed