Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 2/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
| ▸ | MMP7 | P09237 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946888 | 0.90 | ADAM17 (0.48) | ADAM17P2RX3CTSLCTSBCTSS | |
| SCHEMBL6947352 | 0.89 | ADAM17 (0.51) | ADAM17P2RX3TGFBR1MMP2 | |
| SCHEMBL6942217 | 0.88 | ADAM17 (0.49) | ADAM17P2RX3TGFBR1 | |
| SCHEMBL6947353 | 0.87 | ADAM17 (0.46) | ADAM17TGFBR1 | |
| SCHEMBL6940964 | 0.87 | ADAM17 (0.45) | ADAM17TGFBR1 | |
| SCHEMBL6945855 | 0.86 | ADAM17 (0.48) | ADAM17P2RX3TGFBR1 | |
| SCHEMBL6945960 | 0.86 | ADAM17 (0.51) | ADAM17P2RX3TGFBR1MMP2 | |
| SCHEMBL6937788 | 0.86 | ADAM17 (0.51) | ADAM17P2RX3TGFBR1MMP2 | |
| SCHEMBL6943375 | 0.86 | ADAM17 (0.53) | ADAM17P2RX3TGFBR1MMP2MMP13 | |
| SCHEMBL6940024 | 0.85 | ADAM17 (0.48) | ADAM17MMP2MMP13MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |