Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947352 | 0.88 | ADAM17 (0.51) | ADAM17CCNA2CDK2CCNA1CDK5 | |
| SCHEMBL6946888 | 0.87 | ADAM17 (0.48) | ADAM17CCNA2CDK2CCNA1CDK5 | |
| SCHEMBL6943006 | 0.87 | ADAM17 (0.46) | ADAM17TGFBR1 | |
| SCHEMBL7937100 | 0.85 | ADAM17 (0.48) | ADAM17TGFBR1TSHR | |
| SCHEMBL6942217 | 0.85 | ADAM17 (0.49) | ADAM17L3MBTL1TGFBR1 | |
| SCHEMBL6945960 | 0.85 | ADAM17 (0.51) | ADAM17TGFBR1 | |
| SCHEMBL6937788 | 0.85 | ADAM17 (0.51) | ADAM17CCNA2CDK2CCNA1CDK5 | |
| SCHEMBL6943375 | 0.85 | ADAM17 (0.53) | ADAM17CCNA2CDK2CCNA1CDK5 | |
| SCHEMBL6942699 | 0.84 | ADAM17 (0.63) | ADAM17NPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL6945855 | 0.84 | ADAM17 (0.48) | ADAM17TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |