⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9442160 | 0.81 | MAPT (0.37) | — | |
| SCHEMBL873544 | 0.80 | — | — | |
| SCHEMBL1894433 | 0.80 | — | — | |
| SCHEMBL873545 | 0.78 | — | — | |
| SCHEMBL2185277 | 0.76 | MAPT (0.37) | — | |
| SCHEMBL28198217 | 0.76 | MAPT (0.46) | — | |
| SCHEMBL2364872 | 0.76 | GAA (0.38) | — | |
| SCHEMBL19137291 | 0.75 | TDP1 (0.32) | — | |
| SCHEMBL9993851 | 0.75 | MAPT (0.44) | — | |
| SCHEMBL28510539 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0457215-B1 | 3'-deamino-4'-deoxy-4'-amino-8-fluoroanthracyclines and processes for their preparation | MENARINI FARMA IND (IT) | 1996-01-17 | — | — | EP | claimed |
| EP-0457215-A1 | 3'-deamino-4'-deoxy-4'-amino-8-fluoroanthracyclines and processes for their preparation | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1991-11-21 | — | — | EP | claimed |
| JP-4226972-A | — | — | None | — | — | JP | disclosed |
| US-12331057-B2 | Modulators of alpha-1 antitrypsin | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2025-06-17 | — | — | US | disclosed |
| WO-2024251921-A1 | ANTHRACYCLINES | ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC (NL) | 2024-12-12 | — | — | WO | disclosed |
| EP-4474386-A1 | ANTHRACYCLINES | Academisch Ziekenhuis Leiden h.o.d.n. LUMC (NL) | 2024-12-11 | — | — | EP | disclosed |
| US-20240336614-A1 | MODULATORS OF ALPHA-1 ANTITRYPSIN | VERTEX PHARMACEUTICALS INCORPORATED | 2024-10-10 | — | — | US | disclosed |
| US-11884672-B2 | Modulators of alpha-1 antitrypsin | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2024-01-30 | — | — | US | disclosed |
| US-20230193248-A1 | METHODS FOR PROTEIN IDENTIFICATION BASED ON ENCODING REACTIONS | Encodia, Inc. (US) | 2023-06-22 | — | — | US | disclosed |
| EP-3969440-A1 | CONDENSED TRICYCLIC PYRROLES AS ALPHA-1 ANTITRYPSIN MODULATORS | Vertex Pharmaceuticals Incorporated (US) | 2022-03-23 | — | — | EP | disclosed |
| CN-114096542-A | Condensed tricyclic pyrroles as alpha-1 antitrypsin modulators | 弗特克斯药品有限公司 | 2022-02-25 | — | — | CN | disclosed |
| WO-1994024088-A1 | DEALLYLATION REAGENT AND DEALLYLATION METHOD USING SAID REAGENT | RHONE POULENC CHIMIE (FR) | 1994-10-27 | — | — | WO | disclosed |
| US-5221754-A | Easily removable blocking groups to protect primary or secondary amines | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1993-06-22 | — | — | US | disclosed |
| EP-0496836-A4 | SYNTHESIS AND USE OF AMINO ACID FLUORIDES AS PEPTIDE COUPLING REAGENTS | — | 1993-05-05 | — | — | EP | disclosed |
| JP-H04226972-A | 3'-DEAMINO-4'-DEOXY-4'-AMINO-8-FLUOROANTHRACYCLIN AND PREPARATION THEREOF | A MENARINI IND FARM RIUNITE SRL | 1992-08-17 | — | — | JP | disclosed |
| EP-0496836-A1 | SYNTHESIS AND USE OF AMINO ACID FLUORIDES AS PEPTIDE COUPLING REAGENTS. | RES CORP TECHNOLOGIES INC (US) | 1992-08-05 | — | — | EP | disclosed |
| EP-0457215-A1 | 3'-deamino-4'-deoxy-4'-amino-8-fluoroanthracyclines and processes for their preparation | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1991-11-21 | — | — | EP | disclosed |
| WO-1991005564-A1 | SYNTHESIS AND USE OF AMINO ACID FLUORIDES AS PEPTIDE COUPLING REAGENTS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1991-05-02 | — | — | WO | disclosed |
| EP-0401817-A2 | Reagents for rapid peptide synthesis | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1990-12-12 | — | — | EP | disclosed |
| US-4226612-A | Certain herbicidal (2-oxo-3-oxazolidinyl)phenylureas | SHELL OIL COMPANY (US) | 1980-10-07 | — | — | US | disclosed |