Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.79 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | ANPEP | P15144 | 3/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.58 |
| ▸ | ITGAV | P06756 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.55 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943290 | 1.00 | ATM (0.79) | ATML3MBTL1ALDH1A1SMN1; SMN2ANPEP | |
| SCHEMBL2563448 | 0.91 | ALDH1A1 (0.83) | ATML3MBTL1ALDH1A1ANPEPGAA | |
| SCHEMBL8022139 | 0.91 | ALDH1A1 (0.83) | ATML3MBTL1ALDH1A1ANPEPGAA | |
| SCHEMBL9554537 | 0.89 | ALDH1A1 (0.80) | ATML3MBTL1ALDH1A1ANPEPGAA | |
| SCHEMBL14617737 | 0.87 | ATM (0.62) | ATML3MBTL1ALDH1A1SMN1; SMN2ANPEP | |
| SCHEMBL6021043 | 0.85 | ATM (0.69) | ATML3MBTL1SMN1; SMN2ANPEP | |
| SCHEMBL20312211 | 0.83 | L3MBTL1 (0.55) | ATML3MBTL1ALDH1A1ANPEPGAA | |
| SCHEMBL17824375 | 0.82 | L3MBTL1 (0.58) | ATML3MBTL1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL4857954 | 0.82 | L3MBTL1 (0.58) | ATML3MBTL1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL4857947 | 0.82 | L3MBTL1 (0.58) | ATML3MBTL1ALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155002-A4 | METHOD OF SYNTHESIZING BARBITURIC ACID DERIVATIVES AND THEIR USE FOR THE SYNTHESIS OF CHEMICAL LIBRARIES | TRANSTECH PHARMA INC (US) | 2003-03-19 | — | — | EP | disclosed |
| EP-1155002-A1 | METHOD OF SYNTHESIZING BARBITURIC ACID DERIVATIVES AND THEIR USE FOR THE SYNTHESIS OF CHEMICAL LIBRARIES | TransTech Pharma Inc. (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000046211-A1 | METHOD OF SYNTHESIZING BARBITURIC ACID DERIVATIVES AND THEIR USE FOR THE SYNTHESIS OF CHEMICAL LIBRARIES | TRANSTECH PHARMA (US) | 2000-08-10 | — | — | WO | disclosed |