Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | MMP3 | P08254 | 2/20 | 0.34 |
| ▸ | MMP8 | P22894 | 2/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944949 | 0.94 | ADAM17 (0.52) | ADAM17MMP1MMP2MMP3MMP8 | |
| SCHEMBL6939914 | 0.89 | ADAM17 (0.57) | ADAM17MMP2KMT2AMMP9MEN1 | |
| SCHEMBL6943561 | 0.89 | ADAM17 (0.67) | ADAM17MMP2KMT2AMMP9MEN1 | |
| SCHEMBL6939910 | 0.89 | ADAM17 (0.57) | ADAM17MMP2KMT2AMMP9MEN1 | |
| SCHEMBL6947109 | 0.89 | ADAM17 (0.57) | ADAM17MMP2KMT2AMMP9MEN1 | |
| SCHEMBL6942461 | 0.88 | ADAM17 (0.56) | ADAM17MMP2MMP9TGFBR1APP | |
| SCHEMBL6945556 | 0.88 | ADAM17 (0.58) | ADAM17MMP1MMP2MMP13MMP9 | |
| SCHEMBL6943362 | 0.88 | ADAM17 (0.56) | ADAM17MMP2MMP9TGFBR1APP | |
| SCHEMBL6946725 | 0.88 | ADAM17 (0.56) | ADAM17MMP2MMP9TGFBR1APP | |
| SCHEMBL6943975 | 0.88 | ADAM17 (0.56) | ADAM17MMP1MMP2MMP3MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |