Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 15/20 | 0.41 |
| ▸ | NMBR | P28336 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943601 | 0.83 | SIRT2 (0.37) | SIRT2NMBR | |
| SCHEMBL6943555 | 0.78 | SIRT2 (0.49) | SIRT2NMBRMEN1OPRM1OPRD1 | |
| SCHEMBL31370665 | 0.76 | SIRT2 (0.48) | SIRT2NMBRMEN1OPRM1OPRD1 | |
| SCHEMBL10978566 | 0.74 | SIRT2 (0.48) | SIRT2NMBRMEN1OPRM1OPRD1 | |
| SCHEMBL1999641 | 0.73 | SIRT2 (0.49) | SIRT2NMBRMEN1OPRM1OPRD1 | |
| SCHEMBL2002152 | 0.72 | SIRT2 (0.48) | SIRT2NMBRMEN1OPRM1OPRD1 | |
| SCHEMBL22356512 | 0.68 | SIRT2 (0.61) | SIRT2NMBR | |
| SCHEMBL2000374 | 0.68 | SIRT2 (0.61) | SIRT2NMBR | |
| SCHEMBL7081435 | 0.68 | KMT2A (0.37) | MEN1OPRM1OPRD1KMT2A | |
| SCHEMBL1038850 | 0.68 | SIRT2 (0.52) | SIRT2NMBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0928788-B1 | Imidazolidin-4-one derivatives useful as anticancer agents | PFIZER PROD INC (US) | 2003-02-12 | — | — | EP | disclosed |
| US-6194438-B1 | ANTITUMOR AGENTS; ANTICANCER AGENTS; FARNESYL-PROTEIN TRANSFERASE INHIBITOR | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| US-6174903-B1 | INHIBITORS OF THE ENZYME FARNESYL PROTEIN TRANSFERASE AND ARE THEREFORE CAN BE USED AS ANTICANCER AGENT AND ANTITUMOR AGENT | PFIZER INC. | 2001-01-16 | — | — | US | disclosed |
| US-6080769-A | Imidazolidin-4-one derivatives useful as anticancer agents | PFIZER INC. (US) | 2000-06-27 | — | — | US | disclosed |
| EP-1006113-A1 | Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth | Pfizer Products Inc. (US) | 2000-06-07 | — | — | EP | disclosed |
| EP-0928788-A1 | Imidazolidin-4-one derivatives useful as anticancer agents | Pfizer Products Inc. (US) | 1999-07-14 | — | — | EP | disclosed |