Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943282 | 0.92 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1KMT2AHPGDHSD17B10 | |
| SCHEMBL6941106 | 0.90 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1KMT2AHPGDHSD17B10 | |
| SCHEMBL6942607 | 0.86 | CYP3A4 (0.45) | SMN1; SMN2MEN1KMT2AHSD17B10ALDH1A1 | |
| SCHEMBL6944624 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1KMT2AHPGDHSD17B10 | |
| SCHEMBL6941343 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2MEN1KMT2AHPGDHSD17B10 | |
| SCHEMBL6945057 | 0.79 | ALDH1A1 (0.46) | HSD17B10ALDH1A1CYP3A4 | |
| SCHEMBL6942379 | 0.79 | TSHR (0.47) | SMN1; SMN2MEN1KMT2AHPGDHSD17B10 | |
| SCHEMBL6942002 | 0.79 | CALM1 (0.45) | SMN1; SMN2MEN1KMT2AHPGDHSD17B10 | |
| SCHEMBL6937614 | 0.77 | SMN1; SMN2 (0.51) | SMN1; SMN2MEN1KMT2AHPGDHSD17B10 | |
| SCHEMBL6939898 | 0.77 | GAA (0.49) | MEN1KMT2AHPGDALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268471-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072744-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-10-04 | — | — | WO | disclosed |