Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.39 |
| ▸ | ANPEP | P15144 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | SMPD2 | O60906 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942610 | 0.86 | ADAM17 (0.46) | ADAM17ANPEPMMP2MMP9MMP8 | |
| SCHEMBL4481740 | 0.86 | ADAM17 (0.46) | ADAM17ANPEPMMP2MMP9MMP8 | |
| SCHEMBL6944369 | 0.83 | P2RX3 (0.36) | — | |
| SCHEMBL6945999 | 0.79 | ADAM17 (0.43) | ADAM17ANPEPMMP2MMP9MMP8 | |
| SCHEMBL6945409 | 0.79 | ADAM17 (0.43) | ADAM17ANPEPMMP2MMP9MMP8 | |
| SCHEMBL6941767 | 0.79 | ADAM17 (0.46) | ADAM17ANPEPMMP2MMP9MMP8 | |
| SCHEMBL6937757 | 0.78 | ADAM17 (0.34) | ADAM17 | |
| SCHEMBL6942446 | 0.77 | ADAM17 (0.46) | ADAM17ANPEPMMP2MMP9MMP8 | |
| SCHEMBL6940092 | 0.77 | ADAM17 (0.44) | ADAM17ANPEPMMP2MMP9MMP8 | |
| SCHEMBL6942998 | 0.77 | ADAM17 (0.44) | ADAM17ANPEPMMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |