Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946092 | 0.88 | MAPT (0.50) | NPC1RAB9ATDP1ALDH1A1MAPT | |
| SCHEMBL5400271 | 0.84 | RAB9A (0.46) | NPC1RAB9ATDP1ALDH1A1MAPT | |
| SCHEMBL6950018 | 0.82 | MAPT (0.47) | NPC1RAB9ATDP1ALDH1A1MAPT | |
| SCHEMBL6944332 | 0.81 | MAP2K1 (0.54) | NPC1RAB9ATDP1ALDH1A1MAPT | |
| SCHEMBL6946671 | 0.81 | NPC1 (0.42) | NPC1RAB9ATDP1ALDH1A1MAPT | |
| SCHEMBL6948675 | 0.81 | NPC1 (0.42) | NPC1RAB9ATDP1ALDH1A1MAPT | |
| SCHEMBL6945746 | 0.74 | MAP2K1 (0.42) | ALDH3A1KDR | |
| SCHEMBL5391688 | 0.73 | MAPT (0.44) | NPC1RAB9ATDP1MAPTSMN1; SMN2 | |
| SCHEMBL28968698 | 0.72 | ALDH1A1 (0.64) | NPC1RAB9ATDP1ALDH1A1MAPT | |
| SCHEMBL5386919 | 0.72 | MAP2K1 (0.47) | MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202724-B1 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER LAMBERT CO (US) | 2003-10-01 | — | — | EP | claimed |
| JP-2003504401-A | — | — | 2003-02-04 | — | — | JP | claimed |
| CN-1365277-A | Methods of treating chronic pain using MEK inhibitors | VARNER LAMBERT CO (US) | 2002-08-21 | — | — | CN | claimed |
| EP-1202724-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | claimed |
| EP-1150950-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2001-11-07 | — | — | EP | claimed |
| WO-2001005393-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | claimed |
| WO-2000041505-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | claimed |