Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.67 |
| ▸ | EPHX2 | P34913 | 9/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943123 | 0.99 | P2RX7 (0.66) | P2RX7EPHX2KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6941170 | 0.99 | P2RX7 (0.66) | P2RX7EPHX2KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6943597 | 0.98 | P2RX7 (0.65) | P2RX7EPHX2KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6943145 | 0.83 | P2RX7 (0.71) | P2RX7EPHX2KMT2A | |
| SCHEMBL7965380 | 0.83 | P2RX7 (0.71) | P2RX7EPHX2KMT2A | |
| SCHEMBL6941341 | 0.81 | P2RX7 (1.00) | P2RX7EPHX2KMT2A | |
| SCHEMBL6939819 | 0.76 | P2RX7 (0.80) | P2RX7KMT2A | |
| SCHEMBL6940510 | 0.75 | P2RX7 (0.72) | P2RX7KMT2A | |
| SCHEMBL6941252 | 0.73 | P2RX7 (0.69) | P2RX7 | |
| SCHEMBL4133030 | 0.72 | P2RX7 (0.66) | P2RX7EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036058-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2003-03-12 | — | — | EP | claimed |
| US-6242470-B1 | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS, ANTIALLERGENS; IRRITABLE BOWEL SYNDROME; AMIDATION | ASTRAZENECA AB (SE) | 2001-06-05 | — | — | US | claimed |
| EP-1036058-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2003-03-12 | — | — | EP | disclosed |
| US-6242470-B1 | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS, ANTIALLERGENS; IRRITABLE BOWEL SYNDROME; AMIDATION | ASTRAZENECA AB (SE) | 2001-06-05 | — | — | US | disclosed |