Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 15/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939819 | 0.86 | P2RX7 (0.80) | P2RX7 | |
| SCHEMBL6940510 | 0.85 | P2RX7 (0.72) | P2RX7 | |
| SCHEMBL6941341 | 0.81 | P2RX7 (1.00) | P2RX7 | |
| Hydrochloric Acid SCHEMBL6943145 | 0.75 | P2RX7 (0.71) | P2RX7 | |
| SCHEMBL7965380 | 0.75 | P2RX7 (0.71) | P2RX7 | |
| SCHEMBL6941247 | 0.75 | P2RX7 (0.69) | P2RX7 | |
| SCHEMBL6940565 | 0.75 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL4154965 | 0.74 | P2RX7 (0.62) | P2RX7 | |
| SCHEMBL7924727 | 0.74 | ALDH1A1 (0.46) | — | |
| SCHEMBL6939826 | 0.73 | P2RX7 (0.68) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036058-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2003-03-12 | — | — | EP | claimed |
| US-6242470-B1 | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS, ANTIALLERGENS; IRRITABLE BOWEL SYNDROME; AMIDATION | ASTRAZENECA AB (SE) | 2001-06-05 | — | — | US | claimed |
| EP-1036058-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2003-03-12 | — | — | EP | disclosed |
| US-6242470-B1 | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS, ANTIALLERGENS; IRRITABLE BOWEL SYNDROME; AMIDATION | ASTRAZENECA AB (SE) | 2001-06-05 | — | — | US | disclosed |
| EP-1036058-A1 | ADAMANTANE DERIVATIVES | AstraZeneca UK Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029660-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |