Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.55 |
| ▸ | HTR1D | P28221 | 1/20 | 0.55 |
| ▸ | HTR1B | P28222 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 7/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942950 | 0.80 | HTR1A (0.64) | HTR1AHTR1DHTR1BHTR2CSLC6A4 | |
| SCHEMBL31574201 | 0.72 | HTR1A (1.00) | HTR1AHTR1DHTR1BHTR2CSLC6A4 | |
| SCHEMBL22612481 | 0.72 | HTR1A (1.00) | HTR1AHTR1DHTR1BHTR2CSLC6A4 | |
| SCHEMBL8785561 | 0.72 | HTR1A (0.65) | HTR1AHTR1DHTR1BHTR2CSLC6A4 | |
| SCHEMBL27392904 | 0.71 | HTR1A (0.67) | HTR1AHTR1DHTR1BHTR2CSLC6A4 | |
| SCHEMBL8899999 | 0.70 | HTR1A (0.67) | HTR1AHTR1DHTR1BHTR2CSLC6A4 | |
| SCHEMBL6945655 | 0.70 | HTR1A (0.60) | HTR1AHTR1DHTR1BHTR2CSLC6A4 | |
| SCHEMBL6945196 | 0.70 | HTR1A (0.59) | HTR1AHTR1DHTR1BHTR2CSLC6A4 | |
| SCHEMBL13653014 | 0.69 | HTR1A (0.81) | HTR1AHTR1DHTR1BHTR2CSLC6A4 | |
| SCHEMBL6939216 | 0.68 | HTR1A (0.65) | HTR1AHTR1DHTR1BHTR2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | claimed |
| US-5567824-A | CATALYZING THE CYCLIZATION IN PRESENCE OF A SOLVENT AND A PROTON ACCEPTOR | MERCK & CO., INC. (US) | 1996-10-22 | — | — | US | claimed |
| EP-0763032-B1 | PALLADIUM CATALYZED RING CLOSURE OF TRIAZOLYL TRYPTAMINE | MERCK & CO INC (US) | 2003-10-15 | — | — | EP | disclosed |
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | disclosed |
| US-5567824-A | CATALYZING THE CYCLIZATION IN PRESENCE OF A SOLVENT AND A PROTON ACCEPTOR | MERCK & CO., INC. (US) | 1996-10-22 | — | — | US | disclosed |