Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | MASP2 | O00187 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.31 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 3/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | MMP12 | P39900 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942510 | 0.83 | ADAM17 (0.36) | ADAM17CTSCMASP2MMP13MMP1 | |
| SCHEMBL7812038 | 0.81 | CTSC (0.36) | ADAM17CTSCMASP2GRIK1GRIK2 | |
| SCHEMBL6942160 | 0.78 | ADAM17 (0.37) | ADAM17CTSCMASP2MMP13MMP1 | |
| SCHEMBL6989494 | 0.77 | ADAM17 (0.31) | ADAM17CTSCGRIK1GRIK2 | |
| SCHEMBL6940773 | 0.77 | ADAM17 (0.40) | ADAM17CTSCMASP2MMP13MMP1 | |
| SCHEMBL6942646 | 0.75 | ADAM17 (0.40) | ADAM17CTSCMASP2MMP13MMP1 | |
| SCHEMBL6939564 | 0.74 | ADAM17 (0.40) | ADAM17CTSCMASP2MMP13GRIK1 | |
| SCHEMBL6944601 | 0.73 | ADAM17 (0.32) | ADAM17 | |
| SCHEMBL6945625 | 0.72 | ADAM17 (0.33) | ADAM17CTSCMASP2 | |
| SCHEMBL6939999 | 0.72 | ADAM17 (0.33) | ADAM17CTSCMASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |