Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.40 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | MASP2 | O00187 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.30 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939564 | 0.86 | ADAM17 (0.40) | ADAM17CTSCMASP2MMP13GRIK1 | |
| SCHEMBL6946755 | 0.85 | TGFBR1 (0.32) | — | |
| SCHEMBL6942646 | 0.81 | ADAM17 (0.40) | ADAM17CTSCMASP2MMP1MMP9 | |
| SCHEMBL6944612 | 0.79 | ADAM17 (0.38) | ADAM17CTSC | |
| SCHEMBL6942591 | 0.78 | ADAM17 (0.38) | ADAM17CTSC | |
| SCHEMBL8111670 | 0.78 | ADAM17 (0.38) | ADAM17CTSC | |
| SCHEMBL6944954 | 0.78 | ADAM17 (0.37) | ADAM17CTSCMASP2 | |
| SCHEMBL6944604 | 0.77 | ADAM17 (0.36) | ADAM17CTSCMASP2MMP1MMP9 | |
| SCHEMBL6942160 | 0.76 | ADAM17 (0.37) | ADAM17CTSCMASP2MMP1MMP9 | |
| SCHEMBL6943076 | 0.76 | ADAM17 (0.39) | ADAM17GRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |