Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 1.00 |
| ▸ | KDR | P35968 | 12/20 | 0.74 |
| ▸ | FLT1 | P17948 | 6/20 | 0.74 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.74 |
| ▸ | FLT4 | P35916 | 3/20 | 0.74 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.74 |
| ▸ | RET | P07949 | 5/20 | 0.72 |
| ▸ | KIF5B | P33176 | 5/20 | 0.72 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.70 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.70 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.70 |
| ▸ | SRC | P12931 | 3/20 | 0.69 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.69 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.69 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.67 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.67 |
| ▸ | INSR | P06213 | 1/20 | 0.67 |
| ▸ | FBP1 | P09467 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6782656 | 0.90 | EGFR (0.82) | EGFRKDRFLT1FGFR1FLT4 | |
| SCHEMBL5958891 | 0.90 | KDR (0.84) | EGFRKDRFLT1FGFR1FLT4 | |
| Hydrochloric Acid SCHEMBL7211029 | 0.89 | KDR (0.83) | EGFRKDRFLT1FGFR1FLT4 | |
| SCHEMBL3012896 | 0.85 | KDR (1.00) | EGFRKDRFLT1FGFR1FLT4 | |
| SCHEMBL29365791 | 0.85 | KDR (1.00) | EGFRKDRFLT1FGFR1FLT4 | |
| Hydrochloric Acid SCHEMBL7867640 | 0.84 | KDR (0.98) | EGFRKDRFLT1FGFR1FLT4 | |
| Hydrochloric Acid SCHEMBL30078372 | 0.84 | KDR (0.98) | EGFRKDRFLT1FGFR1FLT4 | |
| SCHEMBL5958939 | 0.84 | KDR (1.00) | EGFRKDRFLT1FGFR1FLT4 | |
| SCHEMBL906537 | 0.83 | EPHA2 (0.87) | EGFRKDRFLT1EPHA2EPHB4 | |
| SCHEMBL7209641 | 0.83 | KDR (1.00) | EGFRKDRFLT1FGFR1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1180034-A4 | NOVEL EPIDERMAL GROWTH FACTOR RECEPTOR-BINDING COMPOUNDS FOR POSITRON EMISSION TOMOGRAPHY | HADASIT MED RES SERVICE (IL) | 2003-05-14 | — | — | EP | disclosed |
| EP-1180034-A1 | NOVEL EPIDERMAL GROWTH FACTOR RECEPTOR-BINDING COMPOUNDS FOR POSITRON EMISSION TOMOGRAPHY | HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED (IL) | 2002-02-20 | — | — | EP | disclosed |
| WO-2000072849-A1 | NOVEL EPIDERMAL GROWTH FACTOR RECEPTOR-BINDING COMPOUNDS FOR POSITRON EMISSION TOMOGRAPHY | HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (IL) | 2000-12-07 | — | — | WO | disclosed |
| US-6126917-A | RADIOLABELED COMPOUND | HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (IL) | 2000-10-03 | — | — | US | disclosed |