Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.77 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 7/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | SNCA | P37840 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944793 | 1.00 | MET (0.77) | METLDHAKEAP1NFE2L2STAT3 | |
| SCHEMBL6951877 | 0.92 | MET (0.80) | METKEAP1NFE2L2STAT3MAPT | |
| SCHEMBL6951874 | 0.92 | MET (0.80) | METKEAP1NFE2L2STAT3MAPT | |
| Hydrochloric Acid SCHEMBL5175657 | 0.89 | MET (0.77) | METKEAP1NFE2L2STAT3MAPT | |
| Hydrochloric Acid SCHEMBL5175648 | 0.89 | MET (0.77) | METKEAP1NFE2L2STAT3MAPT | |
| Hydrochloric Acid SCHEMBL5175066 | 0.88 | MET (0.76) | METKEAP1NFE2L2STAT3MAPT | |
| Hydrochloric Acid SCHEMBL5175070 | 0.88 | MET (0.76) | METKEAP1NFE2L2STAT3MAPT | |
| Hmn-214 SCHEMBL5173713 | 0.87 | MET (1.00) | METKEAP1NFE2L2STAT3MAPT | |
| Hmn-214 SCHEMBL29360540 | 0.87 | MET (1.00) | METKEAP1NFE2L2STAT3MAPT | |
| Hmn-214 SCHEMBL5173720 | 0.87 | MET (1.00) | METKEAP1NFE2L2STAT3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0754682-B9 | AMINOSTILBAZOLE DERIVATIVE AND MEDICINE | NIPPON SHINYAKU CO LTD (JP) | 2003-09-17 | — | — | EP | disclosed |
| EP-0754682-B1 | AMINOSTILBAZOLE DERIVATIVE AND MEDICINE | NIPPON SHINYAKU CO LTD (JP) | 2001-10-17 | — | — | EP | disclosed |
| US-5972976-A | FOR TREATMENT OF VARIOUS MALIGNANT TUMORS; (E)-4-(2-(2-(N-acetyl-N-((p-methoxyphenyl)sulfonyl)amino)phenyl)ethenyl)pyridine-1-oxide for example | NIPPON SHINYAKU COMPANY, LIMITED | 1999-10-26 | — | — | US | disclosed |
| EP-0754682-A1 | AMINOSTILBAZOLE DERIVATIVE AND MEDICINE | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1997-01-22 | — | — | EP | disclosed |