Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 2/20 | 0.43 |
| ▸ | MELK | Q14680 | 2/20 | 0.40 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18417279 | 0.83 | CYP19A1 (0.50) | CYP19A1TBXAS1AKT1MELKPRKCZ | |
| SCHEMBL30824478 | 0.79 | CYP19A1 (0.50) | CYP19A1TBXAS1MELKPRKCZPDE10A | |
| SCHEMBL3144610 | 0.79 | CYP19A1 (0.50) | CYP19A1TBXAS1MELKPRKCZPDE10A | |
| SCHEMBL6114863 | 0.77 | CYP1A2 (0.55) | CYP19A1TBXAS1MELKPRKCZPDE10A | |
| SCHEMBL30286452 | 0.76 | CYP19A1 (0.50) | CYP19A1TBXAS1AKT1PDE10AHTR2A | |
| SCHEMBL18417282 | 0.76 | CYP19A1 (0.50) | CYP19A1TBXAS1AKT1PDE10AHTR2A | |
| SCHEMBL6114835 | 0.74 | CYP19A1 (0.51) | CYP19A1TBXAS1MELKPRKCZMEN1 | |
| SCHEMBL11142351 | 0.73 | CYP19A1 (0.48) | CYP19A1TBXAS1AKT1PDE10AHTR2A | |
| SCHEMBL30896286 | 0.73 | CYP19A1 (0.54) | CYP19A1TBXAS1AKT1MELKPRKCZ | |
| SCHEMBL5779124 | 0.73 | MELK (0.55) | CYP19A1TBXAS1AKT1MELKPRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509351-B1 | A method of inhibiting TNF- alpha in a patient in need thereof which comprises administering to said patient an effective amount of a compound for inflamation | SANOFI-SYNTELABO (FR) | 2003-01-21 | — | — | US | disclosed |