Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 2/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.54 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.54 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.44 |
| ▸ | IKBKB | O14920 | 2/20 | 0.42 |
| ▸ | CHUK | O15111 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5801109 | 0.92 | CYP19A1 (0.54) | MELKCYP19A1TBXAS1PRKCZROCK1 | |
| SCHEMBL31472893 | 0.92 | CYP19A1 (0.54) | MELKCYP19A1TBXAS1PRKCZROCK1 | |
| Hydrochloric Acid SCHEMBL29243533 | 0.90 | CYP19A1 (0.53) | MELKCYP19A1TBXAS1PRKCZROCK1 | |
| SCHEMBL28044803 | 0.85 | PRKCZ (0.67) | MELKCYP19A1TBXAS1PRKCZROCK1 | |
| SCHEMBL3821797 | 0.80 | CYP19A1 (0.54) | MELKCYP19A1TBXAS1PRKCZIKBKB | |
| SCHEMBL6897234 | 0.80 | CYP19A1 (0.54) | MELKCYP19A1TBXAS1PRKCZIKBKB | |
| SCHEMBL3153982 | 0.80 | CYP19A1 (0.54) | MELKCYP19A1TBXAS1PRKCZROCK1 | |
| SCHEMBL30896286 | 0.80 | CYP19A1 (0.54) | MELKCYP19A1TBXAS1PRKCZROCK1 | |
| SCHEMBL6042697 | 0.80 | CYP19A1 (0.54) | MELKCYP19A1TBXAS1PRKCZROCK1 | |
| SCHEMBL6114863 | 0.80 | CYP1A2 (0.55) | MELKCYP19A1TBXAS1PRKCZCYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117800909-A | Synthetic method of nitrogen-containing aromatic heterocyclic methylamine | 北京六合宁远医药科技股份有限公司 | 2024-04-02 | — | — | CN | claimed |
| CN-117800909-A | Synthetic method of nitrogen-containing aromatic heterocyclic methylamine | 北京六合宁远医药科技股份有限公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-117800909-A | Synthetic method of nitrogen-containing aromatic heterocyclic methylamine | 北京六合宁远医药科技股份有限公司 | 2024-04-02 | — | — | CN | disclosed |
| EP-1615890-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | WARNER-LAMBERT COMPANY (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004089903-A9 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | WARNER LAMBERT CO (US) | 2005-10-27 | — | — | WO | disclosed |
| WO-2004089903-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-21 | — | — | WO | disclosed |
| US-20040204455-A1 | Piperidine derivative rennin inhibitors | WARNER-LAMBERT COMPANY LLC | 2004-10-14 | — | — | US | disclosed |
| EP-1303491-A1 | THROMBIN INHIBITORS COMPRISING AN AMINOISOQUINOLINE GROUP | Akzo Nobel N.V. (NL) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002004423-A1 | THROMBIN INHIBITORS COMPRISING AN AMINOISOQUINOLINE GROUP | AKZO NOBEL N.V. (NL) | 2002-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204455-A1 | Piperidine derivative rennin inhibitors | REN, ACE, HPN | MELK 2725/4885CYP19A1 4340/4885TBXAS1 3567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.