Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943289 | 0.92 | MAPT (0.74) | MAPTALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL6939980 | 0.88 | MAPT (0.73) | MAPTALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL20639830 | 0.87 | DGAT1 (0.60) | MAPTALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL7462438 | 0.85 | MAPT (0.70) | MAPTALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL14764652 | 0.85 | MAPT (0.80) | MAPTALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL3120176 | 0.84 | MAPT (1.00) | MAPTALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL2548018 | 0.84 | MAPT (1.00) | MAPTALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL9284781 | 0.84 | MAPT (1.00) | MAPTALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL20194400 | 0.83 | MAPT (0.76) | MAPTALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL13568628 | 0.83 | MAPT (0.76) | MAPTALDH1A1GAASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077975-B1 | WATER SOLUBLE AZOLES AS BROAD-SPECTRUM ANTIFUNGALS | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-23 | — | — | EP | disclosed |
| US-6448244-B1 | BROAD-SPECTRUM ANTIFUNGALS, AGAINST WHICH THERE IS NO EXISTING RESISTANCE AND WHICH CAN BE ADMINISTERED INTRAVENOUSLY OR TRANSUNGUALLY | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-09-10 | — | — | US | disclosed |
| EP-1077975-A1 | WATER SOLUBLE AZOLES AS BROAD-SPECTRUM ANTIFUNGALS | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999058529-A1 | WATER SOLUBLE AZOLES AS BROAD-SPECTRUM ANTIFUNGALS | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-11-18 | — | — | WO | disclosed |