Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6949797 | 0.91 | ABCC1 (0.39) | GPBAR1TSHRMAPK1ALDH1A1KDM4E | |
| SCHEMBL6947184 | 0.89 | TSHR (0.43) | TSHR | |
| SCHEMBL6945548 | 0.87 | MEN1 (0.38) | ATMMAPK1ALDH1A1CYP2C9LMNA | |
| SCHEMBL6952002 | 0.87 | MEN1 (0.39) | ATMTSHRMAPK1KDM4EAR | |
| SCHEMBL6769778 | 0.84 | ALDH1A1 (0.41) | ATMGPBAR1TSHRMAPK1ALDH1A1 | |
| SCHEMBL6947302 | 0.83 | TRPM4 (0.39) | TSHRMAPK1ALDH1A1LMNA | |
| SCHEMBL6950838 | 0.81 | MAPT (0.39) | ATMMAPK1ALDH1A1CYP2C9LMNA | |
| SCHEMBL6947204 | 0.80 | MAPK1 (0.37) | TSHRMAPK1ALDH1A1KDM4ELMNA | |
| SCHEMBL6949285 | 0.80 | TSHR (0.44) | TSHRMAPK1ALDH1A1KDM4ECYP2C9 | |
| SCHEMBL6941848 | 0.78 | FDFT1 (0.39) | ATMTSHRMAPK1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003522758-A | — | — | 2003-07-29 | — | — | JP | claimed |
| EP-1254118-A2 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2002-11-06 | — | — | EP | claimed |
| WO-2001058875-A2 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2001-08-16 | — | — | WO | claimed |
| EP-1254118-A2 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001058875-A2 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2001-08-16 | — | — | WO | disclosed |